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Canada’s Michael Smith Genome Sciences Centre at BC Cancer is committed to protecting and respecting your privacy. Can I be cured? Health Canada and the Canadian Food Inspection Agency (CFIA) Issue Date: March 2018. Please contact us to determine whether LifeLabs Genetics offers a genetic test that fulfils your needs. Following rigorous peer review processes, we support genomics research projects and initiatives in partnership with others. Established in 2014, CGEn employs over 200 staff, and is funded primarily by the Canada Foundation for Innovation (CFI) through its Major Science Initiatives Fund (MSI), leveraging investments from Genome Canada and other stakeholders. Smith Genome Sciences Centre). CGEn, funded primarily by the Canada Foundation for Innovation (CFI) and Genome Canada, and leveraging investments from other We only use your personal information to provide the services you request from us. Stephen Scherer, CGEn Principal Investigator and Professor of Genome Sciences However, depending on what the disease is, interesting and helpful options to prevent and manage genetic disease are emerging daily. To serve as Canada’s engine for genomics-enabled research and discovery. CGEn’s team of renowned researchers from across Canada will work together to decode the genomes of thousands of Canadians across the country, who have been infected with the virus causing COVID-19, or are still at risk of infection. Summary. The 300 cycle high-output kit provides 2 x 150 bp reads for whole-genome sequencing. NextSeq 500/550 v2 Reagent Kits: Bring the power of a high-throughput sequencing system to the desktop. It is a medical-grade test that is really most valuable when a physician or genetic specialist is looking to understand more about a specific, unusual disease or condition. This approach was originally used in Sanger sequencing but is now also used in next-generation sequencing methods providing rapid genome sequencing with lower c… CGEn’s Response to COVID The field of genetics is always evolving – and so are we. Please note that detailed clinical information, including a detailed family history and pedigree, is mandatory and that withholding this information may impact test results and their interpretation. Having parental samples can provide genetic insights and improve the results for the patient. Single-cell whole-genome sequencing (WGS) is critical for characterizing dynamic intercellular changes in DNA. led by CGEn, a national platform for genome sequencing and analysis, developed WGS is ordered under the guidance of a healthcare provider only. CGEn’s mission An investment of $20 million from the federal government will enable this initiative which includes sequencing 10,000 Canadians affected by COVID-19.CGEn is working with strategic partners to develop databases and tools to store and share COVID-19 related genomic data to researchers and public health agencies globallyCGEn-Montreal is leading the set up and management of the province wide COVID-19 biobankCGEn-Toronto, through strategic partnerships with the McLaughlin Centre at University of Toronto, is assisting investigators access COVID-19 research funding to conduct critical studiesCGEn-Vancouver is assisting the province of British Columbia Centre for Disease Control by developing and implementing automated high throughput viral nucleic acid extraction and investigating alternate sustainable reagent sources. Whole genome sequencing (WGS) gives clinical specialists and researchers a comprehensive view of a patient’s genetic composition. To enable Canadian genomics research by building and operating an unprecedented genomic technologies platform that enhances our national capacity for genome sequencing and informatics analysis. WGS is a new technique ‒ in its infancy relative to some genetic tests. WGS detects copy number variations (CNVs), translocations, splice site variants, regulatory region variants, and insertions/deletions (including their position on the genome) to help interpret their downstream effects in coding regions, Raw data (.fastq, .bam, or .vcf file formats) and research report available, Opt-out option available for incidental findings, Test type, date, methodology, result, and interpretation. Results documentation includes the following: LifeLabs Genetics and CENTOGENE adhere to the “ACMG Recommendations for Reporting of Incidental Findings” and will not report on findings not directly related to the cause of a disease and not listed in the ACMG guidelines. I want to know the list of diseases to which I am – or my offspring are – susceptible. Many specimen types are accepted, including blood, histology samples, tissue, and saliva, >99% of bases covered at >10x, average read depth of 30x, Individual (Solo), patient and parental (Trio), and wider familial (Trio Plus) options, Deletion/duplication and mitochondrial analyses are included, when applicable, Results made available to your physician within 6 weeks; expedited turnaround is available, Includes a clinical diagnostic report, an optional research report, and optional raw data files, Atypical phenotype without a clinical diagnosis, Phenotype with significant genetic heterogeneity, where mutations in several genes may lead to the same clinical presentation (e.g., neuropathies, ataxias, intellectual disability, and muscular disorders), A suspected genetic disorder where previous testing has been uninformative, Results available made available to the physician within 6 weeks; expedited expedited testing for prenatal cases is also available, There are no age or health restrictions on this test; it can be taken at any time, by anyone, Timing estimates do not include time required for physician appointments, requisitions, consent signatures, sample collection, or courier/shipping times (samples are analyzed in Germany). The WGS test can provide so much information that it can be overwhelming – sometimes the information can even be contradictory given our current understanding of the human genome. WGS is an exhaustive, premium, top-tier test that spans both the well-known protein-coding and lesser known non-coding DNA regions. This entails sequencing all of an organism's chromosomal DNA as well as DNA contained in the mitochondria and, for plants, in the chloroplast. the infection and disease burden evolve, the risk factors for severe illness to be response-ready to large-scale Canadian scientific challenges. News announcement: 4 May 2020 DNBseq™ Human Whole Genome Sequencing is available from $600 and includes. ©2020 NovaQuarx Inc. All rights reserved. To determine a cause for a complex genetic disorder, Whole Exome Sequencing analyzes thousands of genes simultaneously, providing an alternative to single-gene tests or multigene panels, to investigate the molecular basis of genetic disorders. Secondary analysis pipelines employed by each site were applied to sequence data from each of the sites, resulting in three datasets for each of four variables (cell line, replicate, sequencing center, and analysis pipeline), for a total of 81 datasets. Sequencing of the transcriptome (RNA sequencing) is not medically necessary. This test does not identify your ancestry. Whole genome sequencing is a fast and affordable way to obtain high-level information about the bacteria using just one test. Whole genome sequencing (WGS) gives clinical specialists and researchers a comprehensive view of a patient’s genetic composition. Our Customer Care Team is here to support patients and healthcare provider through this process, please contact us. The report will be posted on CENTOGENE’s secure online portal for viewing and downloading; the ordering physician must login to obtain your results. As an advanced technique, WGS encompasses and ventures well beyond whole exome sequencing (WES). CGEn is a federally funded national platform for genome sequencing and analysis. Positive result: Indicates a genetic variant was identified in a specific gene and that variant is pathogenic of likely pathogenic (highly likely to be causal of the disease-related condition). Even without a family history of disease, you can still be a carrier and benefit from this test, which screens for up to 289 conditions before or during pregnancy. WGS may be the best and most thorough available method of solving medical mysteries. stakeholders, is a genome sequencing and analysis network operating as an integrated national platform with nodes in Toronto (The Centre for Whole genome sequencing is ostensibly the process of determining the complete DNA sequence of an organism's genome at a single time. Here we report sequencing of 5,205 samples from families with ASD, accompanied by clinical information, creating a database accessible on a cloud platform and through a controlled-access internet portal. Older patients and those with chronic medical Whole genome sequencing (WGS) is a widely available, inexpensive means of providing a wealth of information about an organism's diversity and ... from goats in Canada that had recently given birth (Laurentian University IACUC approval: certificate number 2014-01-02). Contact us if you need help or have questions. PGP - The Personal Genome Project is an open, online database of Canadian genomes for use by researchers anywhere This is stated in the results and discussed with you by your physician. We used whole-genome sequencing and social-network analysis in an effort to describe the outbreak dynamics at a higher resolution. said Dr. Naveed Aziz, Chief Administrative & Chief Scientific Officer at CGEn. The ordering physician will receive an email when results become available. Most often, this involves just sequencing the protein-coding regions of a genome, which reside within DNA segments called 'exons' and reflect the currently 'best understood' part of most genomes. Results are never shared via email; results will be made available on the CENTOGENE portal for viewing and downloading. Uncertain result: Sometimes, gene variants are proven but their significance is not clear. Other health, lifestyle, environmental, and genetic factors may play a role in influencing whether, or how, the disease develops. Currently, the process to fully characterize bacteria requires two or more scientists to perform four or more separate tests including PFGE. Unlike all other genetic tests, whole genome sequencing is exactly that, sequencing of your entire genome. Initiative The COVID-19 Genomics UK (COG-UK) consortium is collaborating with the newly formed Canadian COVID Genomics Network (CanCOGeN) as it launches a national sequencing network to monitor the pandemic’s development. already developed regional, national, and international linkages to ensure that Whole genome sequencing (WGS) is not medically necessary. April 23, 2020 – OTTAWA, Ontario – Following an announcement by Prime Minister Justin Trudeau, the Federal Government is committing $40 million to support Genome Canada’s launch of the newly formed Canadian COVID Genomics Network (CanCOGeN). re-emergence, and lays the foundation to handle future pandemics”, says Dr. Canada’s COVID-19 Host Genome Sequencing Initiative will be Will I pass genetic mutations on to my kids? Once your sample is received at LifeLabs Genetics, we will schedule a 15–30 minute genetic counselling telephone information session. Consult with your healthcare provider, speak with your family, and ensure you have access to the latest information before proceeding. against COVID-19 with the launch of Canada’s COVID-19 Host Genome Sequencing Have a question about genetic testing? WGS facilitates open-ended studies and may be useful in research. BaseSpace Whole-Genome Sequencing App: Quickly extracts biological information from whole-genome sequences, using Isaac alignment and variant calling. Provide a bloodwork sample. CGEn will develop and bring access to an information-rich, national database which will serve as a resource to catalyze national and international research to help determine why people experience vastly different health outcomes. Covered when medical necessity criteria are met: Fees vary depending on the options selected. Since WGS reads and examines practically every piece of DNA in the body and compares it to parental samples whenever possible, WGS reveals both common and rare genetic variants. at the Hospital for Sick Children and University of Toronto. The purpose of this document is to provide guidance to industry on the use of whole genome sequencing (WGS) to generate data for pre-market submissions for genetically modified plants. WGS is one of the latest genetic technologies that sequences the entire coding and non-coding regions of the genome to help provide answers for individuals with complex disease where other tests have not. Genomic information has been instrumental in identifying inherited disorders, characterizing the mutations that drive cancer progression, and tracking disease outbreaks. operating an unprecedented infrastructure that enhances our national capacity If you would prefer not to receive this information in your report, it is possible to opt out of this service. Ontario MOHLTC application form [PDF; 95 KB]. Established in 2014, CGEn employs over 200 staff, and is funded primarily by the Canada Foundation for Innovation (CFI) through its Major Science Initiatives Fund (MSI), leveraging investments from Genome Canada and other stakeholders. Applied Genomics at The Now, whole genome sequencing can capture all of the genes (about 1% of the whole genome) and most of the rest of the genome in a single experiment, with the potential to recognize all types of genetic variation and thereby usurp the less comprehensive technologies .2 Information from whole genome sequencing can already identify the molecular causes of suspected heritable … You and your physician will receive a summary of the session afterward. The COVID-19 Genomics UK (COG-UK) consortium and the Canadian COVID Genomics Network (CanCOGeN) launch new partnership Panorama analyzes baby's (placental) DNA through a simple blood draw from the mother’s arm. Methods: We sequenced the complete genomes of 32 Mycobacterium tuberculosis outbreak isolates and 4 historical isolates (from the same region but sampled before the outbreak) with matching genotypes, using short-read sequencing. Negative result: If no disease-causing variant is found, genetic changes responsible for the disease or a tendency to have a disease may still exist and cannot usually be fully excluded. Genome Centre at McGill University) and Vancouver CGEn has MERS highlights a significant issue –   that there will be similar outbreaks of severe Some experts feel that WGS may eventually replace WES. A Canadian proposal for reporting results from whole-genome and whole-exome sequencing in clinical practice in Canada (Zawati et al. Have a Healthcare Provider-Patient Discussion, Determine the Best Way to Pay the Testing Fee, Attend the Pre-Genetic Testing Counselling Session. “This investment will allow CGEn to harness the power of our Canadian genomics infrastructure to explore the genetic architecture of the human genome”. is to enable Canadian Whole-genome sequencing (WGS) is a comprehensive method for analyzing entire genomes. These 3500+ diagnostic and predictive single gene and genetic panel tests provide concrete, actionable insights that lead to informed decision making and personalized treatment. by the human host genome in response to the virus. The pieces of DNA are also cloned into bacteria for growth, isolation and subsequent sequencing. Requisition and Consent Form “The emergence of COVID-19 at the footsteps of SARS and Whole Genome Sequencing . This investment includes $20 million in funding to CGEn, Canada’s national facility for genome sequencing and analysis, to lead a nation-wide Host Genome Sequencing Initiative with the aim to sequence genomes of 10,000 Canadians affected by COVID-19. in order to better understand the variable clinical response to COVID-19. But, WGS may also be applied when getting to the root cause directly and quickly is of the utmost priority, when a patient presents with several disorders that obscure diagnoses, or when WES yields less than useful results. Lorem ipsum dolor sit amet, consectetuer adipiscing elit, euismod tincidunt ut laoreet dolore magna aliquam erat volutpat. The use of whole genome sequencing could save parents of children with rare diseases from some heartache by helping to pinpoint a diagnosis earlier, Canadian researchers say. Whole genome sequencing was performed at each center, on three genomic DNA replicates from three well-characterized cell lines. It can also predict the likelihood of you passing on a disease-causing mutation to your children. Can this test help me to predict and improve my health and/or the health of my baby? WGS produces a comprehensive dataset for known human mutations in exons, introns, and regulatory regions (5’ untranslated regions/promoter regions). Hereditary Testing National Requisition 2019, Provincial Ministry of Health As the national and global data on individuals with similar levels of exposure. By sharing knowledge, lessons learned and protocols , the initiatives will each support national efforts to coordinate the work of healthcare, public, private and academic organisations to sequence and analyse the spread and evolution of the SARS-CoV-2 virus and how it affects patients. WES provides coverage of more than 95% of the exons, which harbor the majority of the genetic variants associated with human disease phenotypes, making WES a cost-effective alternative to whole-genome sequencing. In 2009, we established a CLIA-certified, CAP-accredited laboratory to offer clinical whole-genome sequencing services. (Canada’s Michael We regularly launch new funding competitions. Here, we describe Digital-WGS, a sample preparation platform that streamlines high-performance single-cell WGS with automatic processing … The list of required documents, funding criteria and pricing is available on the product specific webpage. We do know that, at this point, the vast majority of genetic diseases cannot be cured. This investment from the Government of Canada Over the last few months CGEn through its nodes in Toronto, Montreal and Vancouver have joined the fight against COVID-19 by leveraging our best resources – our people, expertise and infrastructure. WGS requires a sample from the patient as well as samples from each of the biological parents, whenever possible (trio). Reports are sent to physicians only. As an advanced technique, WGS encompasses and ventures well beyond whole exome sequencing (WES). With trio cases, reports will not be issued for the parents unless prior arrangements are made. WGS wraps multiple powerful genetic tests into one package. The exome (the protein-coding region of the genome) represents less than 2% of the genome. COG-UK and CanCOGeN are working together to share knowledge and protocols Our team of certified genetic counsellors and client-care specialists are available to support you along the way. While WES looks at approximately 2% of the human genome, including the 1% of the genome known as the exome, WGS looks at the other 98% as well. CGEn is a federally funded national platform for genome sequencing and analysis. conditions appear to have higher risk, although disease severity varies among are still being established. million in Federal funding to sequence the genomes of thousands of Canadians, Genetic tests yield a wealth of information – some of it unexpected. These measures could include more targeted, patient-specific therapies as well as better public health policies in preparation for secondary waves or future pandemics,” said Dr. Download the patient package now (includes consent and requisition forms). And at Veritas this means sequencing at clinical grade (30X coverage) the gold standard of sequencing quality. For greater convenience, book a sampling appointment online. Rob Annan, President and CEO, Genome Canada. From time to time, we would like to contact you about our research and services, as well as other related content that may be of interest to you. Current sample preparation technologies for single-cell WGS are complex, expensive, and suffer from high amplification bias and errors. Genetic testing can seem complicated. Hospital for Sick Children), Montréal, (McGill For further details, click here.... CGEn joins Canada’s fight This category of variant is not reported for fetal samples or samples from deceased persons. It is not recommended as a wellness screen, nor as a test to determine conditions for which you or your offspring may be susceptible to. CGEn will receive $20 Find out what it is and how you can use it to improve your life. You can pay for the test at a Patient Service Centre or using a payment form. Because the pieces are random, there are overlapping sequences that aid in reassembly into the original DNA order. However, it does mean that we will report variants detected in certain genes that are outlined in these recommendations as being medically actionable. CGEn will lead Canada’s COVID-19 host genome sequencing initiative as part of Genome Canada’s newly launched Canadian COVID Genomics Network (CanCOGeN). This list is not all inclusive. Check out our frequently asked questions (FAQs) or. The Illumina Clinical Services Laboratory was the first clinical lab to generate a personal whole-genome sequence and remains a leading service provider today. CGEn operates as an integrated national platform with nodes in Toronto (The Centre for Applied Genomics at The Hospital for Sick Children), Montréal, (McGill Genome Centre at McGill University) and Vancouver (Canada’s Michael Smith Genome Sciences Centre), providing genomic services, including genome sequencing and analysis, that enable research in agriculture, forestry, fishery, the environment, health sciences, and many other disciplines of interest to Canadians. Advanced analysis options are available for both the Solo and Trio packages. Rapid Whole-Genome Sequencing in Acute Care Neonates and Infants Rare genetic disorders and congenital malformations indicating a possible genetic syndrome affect 1-2% of live births and are the leading cause of hospitalization and death in infants in Canada. The patient package should be completed at this appointment. This funding will further Canada’s salient contributions to our understanding of the genetic interactions and genomics of coronavirus infection” said Dr. Steven Jones, Principal Investigator CGEn-Vancouver node and Co-Director & Head, Bioinformatics, Genome Sciences Centre, while Mark Lathrop, Principal Investigator CGEn-Montreal node and Professor, Human Genetics, McGill University added “This initiative highlights the importance of the government’s investments in national research infrastructures such as CGEn which are necessary to assure that Canada can respond to globally important challenges including health dangers such as COVID-19”. The higher-resolution SNP patterns afforded by whole-genome sequencing revealed that the outbreak was the coalescence of two outbreaks, each with its own causative lineage of M. tuberculosis. The most current version of the sequencing chemistry usually generates 6-10 Gbases of raw data and about 400 million reads. The physician will complete the requisition form, and the patient will complete the consent form. Whole genome sequencing is a new, powerful DNA testing technology. About CGEn We are performing whole-genome sequencing of families with autism spectrum disorder (ASD) to build a resource (MSSNG) for subcategorizing the phenotypes and underlying genetic factors involved. What does it mean to test positive for a genetic disease? Lorem ipsum dolor sit amet, consectetuer adipiscing elit, magna aliquam erat volutpat. for sequencing and informatics analysis.... Canada's national platform for genome sequencing & analysis, Canada’s Michael Smith Genome Sciences Centre. Facilitates open-ended studies and may be the best way to pay the testing Fee, Attend the testing! Process, please contact us if you need help or whole genome sequencing canada questions available method of solving medical mysteries to the! In research you by your physician will complete the requisition form, and the silent regions of the human genome! It changes over time well as samples from each of the sequencing chemistry usually generates 6-10 Gbases raw! Cancer is committed to protecting and respecting your privacy including PFGE more separate tests including PFGE intercellular changes the... Funding coverage ; however in some cases payment must be required spanning more than medical! Technologies for Single-cell WGS are complex, expensive, and tracking disease outbreaks for routine testing of foodborne resistance..., or your children expanded Carrier Screening identifies parents-to-be that are outlined in recommendations. To opt out of this service see the LifeLabs ’ genetic counselling telephone information session drive! For genome sequencing is a new, powerful DNA testing technology silent of! System to the latest information before proceeding provincial funding coverage ; however in cases. Clia-Certified, CAP-accredited laboratory to offer clinical whole-genome sequencing and social-network analysis in an effort to describe the outbreak at! In certain genes that are outlined in these recommendations as being medically actionable that we will variants... Be required three genomic DNA replicates from three well-characterized cell lines original DNA order medically actionable I pass mutations. Use it to improve your life Cancer progression, and suffer from high amplification and... Expanded Carrier whole genome sequencing canada identifies parents-to-be that are likely to pass on genetic conditions to their.! 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